A global review on short peptides: frontiers and perspectives

V Apostolopoulos, J Bojarska, TT Chai, S Elnagdy… - Molecules, 2021 - mdpi.com
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Anti-CD20 agents for multiple sclerosis: spotlight on ocrelizumab and ofatumumab

D Florou, M Katsara, J Feehan, E Dardiotis… - Brain Sciences, 2020 - mdpi.com
Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has
been largely underestimated, and the disease was considered a T-cell-mediated disorder …

Targeting antigens to dendritic cell receptors for vaccine development

V Apostolopoulos, T Thalhammer… - Journal of drug …, 2013 - Wiley Online Library
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system
which play a key role in regulating immune responses. Depending on the method of antigen …

Microbiome in multiple sclerosis: Where are we, what we know and do not know

MK Boziki, E Kesidou, P Theotokis, AFA Mentis… - Brain sciences, 2020 - mdpi.com
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …

Review cyclic peptides on a merry‐go‐round; towards drug design

A Tapeinou, MT Matsoukas, C Simal… - Peptide Science, 2015 - Wiley Online Library
Peptides and proteins are attractive initial leads for the rational design of bioactive
molecules. Several natural cyclic peptides have recently emerged as templates for drug …

A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: A therapeutic approach to inflammation

MC Domínguez-Horta, A Serrano-Díaz… - Frontiers in …, 2023 - frontiersin.org
Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They
are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the …

Streptococcusthermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

N Dargahi, J Matsoukas, V Apostolopoulos - Brain sciences, 2020 - mdpi.com
Probiotic bacteria have beneficial effects to the development and maintenance of a healthy
microflora that subsequently has health benefits to humans. Some of the health benefits …

[HTML][HTML] Matrix metalloproteinases–From the cleavage data to the prediction tools and beyond

P Cieplak, AY Strongin - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …