[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review

AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?

J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …

High-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products

T El-Elimat, M Figueroa, BM Ehrmann… - Journal of natural …, 2013 - ACS Publications
A major problem in the discovery of new biologically active compounds from natural
products is the reisolation of known compounds. Such reisolations waste time and …

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

H Wu, J Guo, S Chen, X Liu, Y Zhou, X Zhang… - … of pharmaceutical and …, 2013 - Elsevier
Over the past few years, the applications of liquid chromatography coupled with mass
spectrometry (LC–MS) in natural product analysis have been dramatically growing because …

Advances in techniques for profiling crude extracts and for the rapid identificationof natural products: Dereplication, quality control and metabolomics

JL Wolfender, G Marti… - Current organic …, 2010 - ingentaconnect.com
Thanks to the important advances registered over the last decade in analytical techniques,
profiling methods for the analysis of crude extracts from plant origin or from other biological …

Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soils

JO Falkinham III, TE Wall, JR Tanner… - Applied and …, 2009 - Am Soc Microbiol
Anecdotes, both historical and recent, recount the curing of skin infections, including diaper
rash, by using red soils from the Hashemite Kingdom of Jordan. Following inoculation of red …

Reviewing Colchicaceae alkaloids–perspectives of evolution on medicinal chemistry

S Larsson, N Ronsted - Current topics in medicinal chemistry, 2014 - ingentaconnect.com
The subject of chemosystematics has provided insight to both botanical classification and
drug development. However, degrees of subjectivity in botanical classifications and limited …

Chemical constituents from Colchicum palaestinum (Baker) C. Archer with the assessment of its antioxidant, wound scratch, and tyrosinase repressive potential

MA Asmaey, MM Salem, M Emam… - South African Journal of …, 2023 - Elsevier
Plant-natural products are used in several cosmetic applications as whitening agents.
However, various Colchicum species rich in bioactive secondary metabolites that possess …

A new insight into toxicity of colchicine analogues by molecular docking analysis based on intestinal tight junction protein ZO-1

J Liu, R Gao, X Gu, B Yu, Y Wu, Q Li, P Xiang, H Xu - Molecules, 2022 - mdpi.com
Colchicine (COL) is a well-known plant alkaloid long used for medical purposes due to the
selective anti-inflammatory effect on acute gouty arthritis. It is also a kind of mitosis toxin with …

Colchicine semisynthetics: chemotherapeutics for cancer?

G Sivakumar - Current medicinal chemistry, 2013 - ingentaconnect.com
Nitrogen-containing bioactive alkaloids of plant origin play a significant role in human health
and medicine. Several semisynthetic antimitotic alkaloids are successful in anticancer drug …