Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been
diagnosed in an increasing number of children around the world. Existing data suggest that …

Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers
through methylation and molecular rearrangement. These functions take place in fatty acid …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of
developing cognitive disorders and dementia. This risk is generally explained by the high …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Background Recent studies suggest that vascular disease may contribute to the cause of
Alzheimer disease (AD). Since elevated plasma total homocysteine (tHcy) level is a risk …