Cellular quiescence is a state characterized by decreased cell size and metabolic activity. In
quiescent naı̈ve lymphocytes, antigen recognition with appropriate co-stimulation triggers …

The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides
important signals regulating clonal expansion, antibody production and isotype switching, as …

Transcription factors of the Forkhead Box, class O (FOXO) family promote cell-cycle arrest
and/or apoptosis in a variety of cell types. Mitogenic stimuli inactivate FOXO function by way …

Cyclin D2 is the only D-type cyclin expressed in mature mouse B-lymphocytes, and its
expression is associated with retinoblastoma protein (pRB) and pRB-related protein …

CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules
and has been shown to play important roles in T cell-mediated B lymphocyte activation …

B cells undergo epigenetic remodeling as they differentiate into Ab-secreting cells (ASC).
LSD1 is a histone demethylase known to decommission active enhancers and cooperate …

The epidermis consists of a squamous epithelium continuously replenished by committed
stem cells, which can either self-renew or differentiate. We demonstrated previously that E2F …

Surface‐expressed BCR mediates the proliferation and expansion of antigen‐specific B
lymphocytes during a humoral immune response. Although several studies extensively …

The p85α subunit of PI3-K and Btk are two crucial components of the B-cell receptor (BCR)
signalling pathway. In the present study, we showed that primary splenic B cells from p85α …

ABSTRACT B lymphocytes comprise a major component of the adaptive mammalian
immune system, having the exclusive ability to produce and secrete immunoglobulins (Ig) of …