Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Cells translate extracellular signals to regulate processes such as differentiation,
metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

AbstractUniversity of Conneticut School of Medicine The public and health care providers
are increasingly curious about the potential medical benefits of Cannabis. In vitro and in vivo …

Angiotensin II (AngII), as an octapeptide hormone normally ionized at physiological pH,
cannot cross cell membranes and thus, relies on, two (mainly) G protein-coupled receptor …

Abstract Purpose of Review The renin-angiotensin-aldosterone system (RAAS) plays
important roles in regulating blood pressure and body fluid, which contributes to the …

G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved
and clinical prescribed drugs and represent the largest and most structurally diverse family …

Angiotensin II (AngII) uses two distinct G protein-coupled receptor (GPCR) types, AT 1 R and
AT 2 R, to exert a plethora of physiologic effects in the body and to significantly affect …