Galectins are carbohydrate-binding proteins that are involved in many physiological
functions, such as inflammation, immune responses, cell migration, autophagy and …

Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this
pathway is associated with many diseases including cancer, infection, metabolic disease …

Endomembrane damage elicits homeostatic responses including ESCRT-dependent
membrane repair and autophagic removal of damaged organelles. Previous studies have …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum
stress and activation of the unfolded protein response, is a hallmark of several …

Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L
(Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger …

Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A
moiety, inducing inflammatory caspase oligomerization and activation, which is identified as …

Receptor tyrosine kinases (RTKs) constitute a large group of cell surface proteins that
mediate communication of cells with extracellular environment. RTKs recognize external …

Numerous lines of evidence support the premise that the misfolding and subsequent
accumulation of SNCA/α-synuclein (synuclein alpha) is responsible for the underlying …

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids interact with
each other in the mammalian plasma membranes, forming dynamic microdomains. How …