A complex antioxidant system has been developed in mammals to relieve oxidative stress.
However, excessive reactive species derived from oxygen and nitrogen may still lead to …

Excess reactive oxygen species production and free radical formation can lead to oxidative
stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the …

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …

Context: Paracetamol overdose is a predominant cause of hepatotoxicity in both humans
and experimental animals. Objective: In this study, we investigated the protective effect of …

METHODS: Male mice were divided into four groups. Group 1 (control, n= 8); was fed with
distilled water; Group 2 [N-acetyl-P-aminophenol (APAP), n= 8]; was fed with a single dose …

We compared the relative protective abilities of silymarin and l-methionine pre-treatment in
acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing …

The aim of the present study was to validate the antioxidant effect of whey protein
hydrolysate (WPH) using a small animal model. Paracetamol is common drug that is safe at …

Silymarin, derived from Silybum marianum, has been used in traditional medicine for various
ailments. In this study, the cardioprotective and hepatoprotective effects of silymarin against …

Excessive use of plant protein can cause various diseases, and functional additives have
been proven to improve the health of aquatic fish but its underlying mechanism is still …

目的氨甲蝶呤(methotrexate， MTX) 是导致药物性肝损伤最常见的药物， 其致病机制与线粒体
功能障碍引起的氧化应激有关。 超氧化物歧化酶(superoxide dismutase， SOD) …