Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NN Keum, E Giovannucci - Nature reviews Gastroenterology & …, 2019 - nature.com
Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

General insight into cancer: An overview of colorectal cancer

SM Alzahrani, HA Al Doghaither… - Molecular and …, 2021 - spandidos-publications.com
Cancer is currently among the leading causes of mortality globally. Colorectal cancer (CRC)
ranks second among the most common types of cancer in terms of mortality worldwide. This …

The molecular hallmarks of the serrated pathway in colorectal cancer

FDE De Palma, V D'argenio, J Pol, G Kroemer… - Cancers, 2019 - mdpi.com
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Cellular and epigenetic drivers of stem cell ageing

M Ermolaeva, F Neri, A Ori, KL Rudolph - Nature reviews Molecular cell …, 2018 - nature.com
Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

Colorectal cancer: epidemiology, disease mechanisms and interventions to reduce onset and mortality

V Aran, AP Victorino, LC Thuler, CG Ferreira - Clinical colorectal cancer, 2016 - Elsevier
Colorectal cancer (CRC) is a multifactorial disease resulting from lifestyle, genetic, and
environmental factors. There are hereditary and non-hereditary CRC types; however, the …

The rising incidence of younger patients with colorectal cancer: questions about screening, biology, and treatment

LC Connell, JM Mota, MI Braghiroli, PM Hoff - Current treatment options in …, 2017 - Springer
Opinion statement Colorectal cancer (CRC) is the third leading cancer diagnosed globally
and an important cause of cancer-related mortality. Of interest, while we have witnessed a …

[HTML][HTML] Emerging roles of cystathionine β-synthase in various forms of cancer

K Ascenção, C Szabo - Redox biology, 2022 - Elsevier
The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

Colon cancer: from epidemiology to prevention

K Katsaounou, E Nicolaou, P Vogazianos, C Brown… - Metabolites, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …