This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

While a pathway for Ca2+ accumulation into mitochondria has long been established, its
functional significance is only now becoming clear in relation to cell physiology and …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Studies in Bristol in the 1960s and 1970s, led to the recognition that four mitochondrial
dehydrogenases are activated by calcium ions. These are FAD-glycerol phosphate …

This review deals with the permeability transition (PT) of isolated mitochondria, a field
spawned at the very beginning of mitochondrial research by the observation that the …

This review provides a selective history of how studies of mitochondrial cation transport (K+,
Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Calcium is thought to play an important role in regulating mitochondrial function. Evidence
suggests that an increase in mitochondrial calcium can augment ATP production by altering …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …