MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to
inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the …

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory
component is present also in the microenvironment of tumors that are not epidemiologically …

Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-
refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To …

Recently, the inhibition of epithelial-mesenchymal-transition (EMT) by p53 has been
described as a new mode of tumor suppression which presumably prevents metastasis …

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To
identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA …

In a genome‑wide screen for microRNAs regulated by the transcription factor encoded by
the p53 tumor suppressor gene we found that after p53‑activation the abundance of thirty …

Recently, microRNAs, which are regulated by the transcription factor encoded by the tumor
suppressor gene p53, were identified independently by seven groups. Their studies …