Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Introduction: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful
methodology to study protein dynamics, protein folding, protein-protein interactions, and …

Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

The integration of biophysical data from multiple sources is critical for developing accurate
structural models of large multiprotein systems and their regulators. Mass spectrometry (MS) …

The practice of HDX-MS remains somewhat difficult, not only for newcomers but also for
veterans, despite its increasing popularity. While a typical HDX-MS project starts with a …

For hydrogen–deuterium exchange mass spectrometry (HDX-MS) to have an increased role
in quality control of biopharmaceuticals, H for D back-exchange occurring during protein …

Biological processes are the result of noncovalent, protein–ligand interactions, where the
ligands range from small organic and inorganic molecules to lipids, nucleic acids, peptides …

The pitcher secretions of the Nepenthes genus of carnivorous plants contain a proteolytic
activity that is very useful for hydrogen/deuterium exchange mass spectrometry (HX-MS) …

Chromatographic separations at subzero temperature significantly improve the precision of
back-exchange-corrected hydrogen–deuterium exchange mass spectrometry (HDX-MS) …