Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?

JD Wilson, EM Hammond, GS Higgins… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm

E Schüler, M Acharya, P Montay‐Gruel… - Medical …, 2022 - Wiley Online Library
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …

Experimental platform for ultra-high dose rate FLASH irradiation of small animals using a clinical linear accelerator

E Schüler, S Trovati, G King, F Lartey, M Rafat… - International Journal of …, 2017 - Elsevier
Purpose A key factor limiting the effectiveness of radiation therapy is normal tissue toxicity,
and recent preclinical data have shown that ultra-high dose rate irradiation (> 50 …

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

Y Gao, R Liu, CW Chang, S Charyyev… - Journal of Applied …, 2022 - Wiley Online Library
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

PHASER: A platform for clinical translation of FLASH cancer radiotherapy

PG Maxim, SG Tantawi, BW Loo Jr - Radiotherapy and Oncology, 2019 - Elsevier
Pluridirectional high-energy agile scanning electronic radiotherapy (PHASER) is next-
generation medical linac technology for ultra-rapid highly conformal image-guided radiation …

High dose‐per‐pulse electron beam dosimetry: usability and dose‐rate independence of EBT3 Gafchromic films

M Jaccard, K Petersson, T Buchillier… - Medical …, 2017 - Wiley Online Library
Purpose The aim of this study was to assess the suitability of Gafchromic EBT3 films for
reference dose measurements in the beam of a prototype high dose‐per‐pulse linear …

Flash radiotherapy: Innovative cancer treatment

JCL Chow, HE Ruda - Encyclopedia, 2023 - mdpi.com
Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …

[HTML][HTML] FLASH radiotherapy treatment planning and models for electron beams

M Rahman, A Trigilio, G Franciosini, R Moeckli… - Radiotherapy and …, 2022 - Elsevier
The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …

On the capabilities of conventional x‐ray tubes to deliver ultra‐high (FLASH) dose rates

M Bazalova‐Carter, N Esplen - Medical physics, 2019 - Wiley Online Library
Purpose By means of Monte Carlo (MC) simulations and indirect measurements, we have
evaluated the maximum dose rates achievable with conventional x‐ray tubes and related …