Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

M Ahmadi, J Rezaie - Journal of translational medicine, 2020 - Springer
Angiogenesis is a multistep process and various molecules are involved in regulating it.
Extracellular vesicles are cell-derived particles, secreted from several types of cells and are …

Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis

AB Ghaemmaghami, M Mahjoubin-Tehran… - Cell Communication and …, 2020 - Springer
Malignant gliomas are the most common and deadly type of central nervous system tumors.
Despite some advances in treatment, the mean survival time remains only about 1.25 years …

Potential roles of tumor-derived exosomes in angiogenesis

N Ludwig, TL Whiteside - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Tumor-derived exosomes (TEX) and their role in tumor progression by
accelerating angiogenesis are of great current interest. A better understanding of the …

LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway

EP Cuevas, P Eraso, MJ Mazón, V Santos… - Scientific reports, 2017 - nature.com
Abstract Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the
aggressiveness of cancer cells. EMT is triggered by activation of different transcription …

Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration

C Salomon, S Yee, K Scholz-Romero… - Frontiers in …, 2014 - frontiersin.org
Background: Vascular smooth muscle cells (VSMCs) migration is a critical process during
human uterine spiral artery (SpA) remodeling and a successful pregnancy. Extravillous …

Extracellular vesicles in brain tumor progression

E D'Asti, S Chennakrishnaiah, TH Lee… - Cellular and molecular …, 2016 - Springer
Brain tumors can be viewed as multicellular 'ecosystems' with increasingly recognized
cellular complexity and systemic impact. While the emerging diversity of malignant disease …

Hypoxia preconditioned DPSC-derived exosomes regulate angiogenesis via transferring LOXL2

B Li, A Liang, Y Zhou, Y Huang, C Liao, X Zhang… - Experimental cell …, 2023 - Elsevier
Hypoxia was proved to enhance the angiogenesis of stem cells. However, the mechanism of
the angiogenic potential in hypoxia-pretreated dental pulp stem cells (DPSCs) is poorly …

Expression, function and clinical application of stanniocalcin‐1 in cancer

F Zhao, G Yang, M Feng, Z Cao, Y Liu… - Journal of Cellular …, 2020 - Wiley Online Library
The glycoprotein stanniocalcin‐1 functions as a regulatory endocrine hormone that
maintains the balance of calcium and phosphorus in bony fish and as a paracrine/autocrine …

Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1

Y Li, ZC He, XN Zhang, Q Liu, C Chen, Z Zhu, Q Chen… - Cancer letters, 2018 - Elsevier
Glioblastoma (GBM) is a fatal tumor and comprises heterogeneous cells in which a
subpopulation with stem cell-like properties is included. Cancer cells with stem cell-like …