[HTML][HTML] Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments

ME Williams, SS Zulu, DJ Stein, JA Joska… - Neurobiology of …, 2020 - Elsevier
HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders
due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 …

Combined HIV-1 Tat and oxycodone activate the hypothalamic-pituitary-adrenal and-gonadal axes and promote psychomotor, affective, and cognitive dysfunction in …

MF Salahuddin, AN Qrareya, F Mahdi, D Jackson… - Hormones and …, 2020 - Elsevier
The majority of HIV+ patients present with neuroendocrine dysfunction and~ 50%
experience co-morbid neurological symptoms including motor, affective, and cognitive …

Monoacylglycerol lipase inhibitor MJN110 reduces neuronal hyperexcitability, restores dendritic arborization complexity, and regulates reward-related behavior in …

AF League, BL Gorman, DJ Hermes… - Frontiers in …, 2021 - frontiersin.org
While current therapeutic strategies for people living with human immunodeficiency virus
type 1 (HIV-1) suppress virus replication peripherally, viral proteins such as transactivator of …

High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice

N Dos Santos, LS Novaes, G Dragunas… - Scientific reports, 2019 - nature.com
Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by
demyelination of the Central Nervous System. Immune cells activation and release of pro …

Spinal alarmin HMGB1 and the activation of TLR4 lead to chronic stress-induced nociceptive hypersensitivity in rodents

EJ Rodríguez-Palma, I Velazquez-Lagunas… - European Journal of …, 2023 - Elsevier
Chronic stress affects millions of people around the world, and it can trigger different
behavioral disorders like nociceptive hypersensitivity and anxiety, among others. However …

Tight junction proteins in the small intestine and prefrontal cortex of female rats exposed to stress of chronic isolation starting early in life

P Karailiev, N Hlavacova, M Chmelova… - …, 2021 - Wiley Online Library
Background Simultaneous evaluation of barrier protein expression in the gut and the brain
and their modulation under stress conditions have not been studied before now. As the …

Mechanisms of residual immune activation in HIV-1-infected human lymphoid tissue ex vivo

V Mercurio, W Fitzgerald, C Vanpouille, I Molodtsov… - AIDS, 2021 - journals.lww.com
Objective: HIV-1 infection triggers immune activation, as reflected by the upregulation of
various cytokines. This immune activation remains elevated despite antiretroviral therapy …

Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes

K Chen, T Phan, A Lin, L Sardo, AR Mele… - PLoS …, 2020 - journals.plos.org
Despite antiretroviral therapy human immunodeficiency virus type-1 (HIV-1) infection results
in neuroinflammation of the central nervous system that can cause HIV-associated …

Role of glial CCR5 in mediating HIV-1 Tat and opiate neurotoxicity and behavioral phenotype

S Kim - 2019 - scholarscompass.vcu.edu
Human immunodeficiency virus type 1 (HIV-1) persists in certain CNS cell populations,
despite peripheral control of the infection with modern antiretroviral therapy. Infected and/or …

[PDF][PDF] High dose of dexamethasone protects against eAe-induced motor deficits but impairs learning/memory in C57BL/6 mice

CD Munhoz - core.ac.uk
Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by
demyelination of the Central Nervous System. Immune cells activation and release of pro …