New insights into activation and function of the AMPK

GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

AMPK: restoring metabolic homeostasis over space and time

E Trefts, RJ Shaw - Molecular cell, 2021 - cell.com
The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Mapping of the plant SnRK1 kinase signalling network reveals a key regulatory role for the class II T6P synthase-like proteins

J Van Leene, D Eeckhout, A Gadeyne, C Matthijs… - Nature Plants, 2022 - nature.com
The central metabolic regulator SnRK1 controls plant growth and survival upon activation by
energy depletion, but detailed molecular insight into its regulation and downstream targets is …

A guide to the regulation of selective autophagy receptors

A Gubas, I Dikic - The FEBS journal, 2022 - Wiley Online Library
Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy

P Koutsifeli, U Varma, LJ Daniels, M Annandale… - Journal of Biological …, 2022 - ASBMB
Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …

[HTML][HTML] AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

C Collodet, M Foretz, M Deak, L Bultot… - The FASEB …, 2019 - ncbi.nlm.nih.gov
AMPK is a central regulator of energy homeostasis. AMPK not only elicits acute metabolic
responses but also promotes metabolic reprogramming and adaptations in the long-term …

AMP-activated protein kinase: do we need activators or inhibitors to treat or prevent cancer?

FM Russell, DG Hardie - International Journal of Molecular Sciences, 2020 - mdpi.com
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy balance. In
response to metabolic stress, it acts to redress energy imbalance through promotion of ATP …

Glycogen‐binding protein STBD1: Molecule and role in pathophysiology

Q Tang, M Liu, H Zhao, L Chen - Journal of Cellular Physiology, 2023 - Wiley Online Library
Starch‐binding domain‐containing protein 1 (STBD1) is a glycogen‐binding protein
discovered in skeletal muscle gene differential expression that is pivotal to cellular energy …

[HTML][HTML] Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

NJ Hoffman, J Whitfield, NR Janzen, MR Belhaj… - Molecular …, 2020 - Elsevier
Objective Glycogen is a major energy reserve in liver and skeletal muscle. The master
metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its …

How mass spectrometry can be exploited to study AMPK

MH Rider, D Vertommen, M Johanns - Essays in biochemistry, 2024 - portlandpress.com
AMP-activated protein kinase (AMPK) is a key regulator of metabolism and a recognised
target for the treatment of metabolic diseases such as Type 2 diabetes (T2D). Here, we …