Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology

JC Menezes, MF Diederich - European Journal of Medicinal Chemistry, 2019 - Elsevier
Natural products like coumarins, chalcones, and resveratrol have inherent biological activity
in several models of diseases; therefore, their natural dimeric forms are highlighted in this …

Visible light-induced strain-release transformations of bicyclo [1.1. 0] butanes

QB Zhang, F Li, B Pan, S Zhang, XG Yue, Q Liu - Green Chemistry, 2024 - pubs.rsc.org
Bicyclo [1.1. 0] butanes, as structurally unique compounds with high strained energy and
diverse chemical properties, are becoming increasingly popular building blocks in organic …

Enantioselective [2+ 2] photocycloaddition via iminium ions: catalysis by a sensitizing chiral Brønsted acid

F Pecho, Y Sempere, J Gramuller… - Journal of the …, 2021 - ACS Publications
N, O-Acetals derived from α, β-unsaturated β-aryl substituted aldehydes and (1-
aminocyclohexyl) methanol were found to undergo a catalytic enantioselective [2+ 2] …

Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and …

M Ginovyan, H Javrushyan, G Petrosyan… - … International Journal of …, 2023 - Elsevier
Cancer continues to be a leading cause of death worldwide, making the development of
new treatment methods crucial in the fight against it. With cancer incidence rates increasing …

Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury

AO Afolabi, TM Akhigbe, AF Odetayo, DC Anyogu… - Molecules, 2022 - mdpi.com
Ethnopharmacological relevance: Oxidative stress is a key player in intestinal
ischemia/reperfusion (I/R) injury (IIRI) with a tendency to trigger systemic inflammatory …

Nickel‐Catalyzed Tunable Enantioconvergence and Kinetic Resolution in the Coupling of Tertiary Cyclobutenols with Arylboroxines

X Yan, Y Zhu, Y Xia - Angewandte Chemie International Edition, 2023 - Wiley Online Library
We report that a nickel catalyst system with a modified 1, 1′‐spirobiindane‐7, 7′‐diol‐
phosphoramidite (SPINOL) as the chiral ligand can enable the coupling of tertiary …

A general catalytic synthetic strategy for highly strained methylenecyclobutanes and spiromethylenecyclobutanes

H Zhao, Y Lin, M Jiang, B Su - Chemical Science, 2023 - pubs.rsc.org
Highly strained methylenecyclobutanes (MCBs) are intriguing scaffolds in synthetic
chemistry and drug discovery, but there is no such strategy that enables the synthesis of …

Supramolecular template-assisted catalytic [2+ 2] photocycloaddition in homogeneous solution

F Wang, S Bai, QW Zhu, ZH Wei, YF Han - CCS Chemistry, 2023 - chinesechemsoc.org
Supramolecular interactions can help recognize and organize substrates around an
enzyme's active sites and subsequently assemble a new molecule in a certain way. Inspired …

Catalytic enantioselective synthesis of benzocyclobutenols and cyclobutanols via a sequential reduction/C–H functionalization

J Chen, Z Shi, C Li, P Lu - Chemical Science, 2021 - pubs.rsc.org
We report here a sequential enantioselective reduction/C–H functionalization to install
contiguous stereogenic carbon centers of benzocyclobutenols and cyclobutanols. This …

Expanding the chemical space of 1, 2-difunctionalized cyclobutanes

AV Chernykh, OV Kudryk, OS Olifir… - The Journal of …, 2023 - ACS Publications
An efficient approach to the synthesis of previously unavailable or hardly accessible 1, 2-
difunctionalized cyclobutanes (mostly with NH2/NHBoc, OH, SH, or SO2F groups attached to …