Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy

G Fumagalli, L Monza, G Cavaletti, R Rigolio… - Frontiers in …, 2021 - frontiersin.org
Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Vincristine-induced peripheral neuropathy: a mini-review

G Li, Y Hu, D Li, Y Zhang, H Guo, Y Li, F Chen, J Xu - Neurotoxicology, 2020 - Elsevier
Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other
chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia …

Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating …

A Yardim, FM Kandemir, S Ozdemir, S Kucukler… - Neurotoxicology, 2020 - Elsevier
In the present study, the protective effects of quercetin on peripheral neurotoxicity caused by
vincristine, which is used effectively in the treatment of various types of cancers, were …

The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats

HS Semis, FM Kandemir, O Kaynar, T Dogan… - Life Sciences, 2021 - Elsevier
Paclitaxel (PTX), which is widely used in the treatment of solid tumors, leads to dose
limitation because it causes peripheral neuropathy. This study was conducted to evaluate …

[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain

A Khan, B Shal, AU Khan, R Ullah, MW Baig… - International journal of …, 2021 - mdpi.com
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …

Impact of adipose tissue depot harvesting site on the multilineage induction capacity of male rat adipose-derived mesenchymal stem cells: An in vitro study

HM El-Husseiny, M Kaneda, EA Mady… - International Journal of …, 2023 - mdpi.com
Recently, substantial attention has been paid toward adipose-derived mesenchymal stem
cells (AdMSCs) as a potential therapy in tissue engineering and regenerative medicine …

Chemical profiling of Justicia vahlii Roth.(Acanthaceae) using UPLC-QTOF-MS and GC-MS analysis and evaluation of acute oral toxicity, antineuropathic and …

A Basit, S Ahmad, A Naeem, M Usman, I Ahmed… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Justicia vahlii Roth.(Acanthaceae), also called as
kodasoori and bhekkar is an annual therophyte erect or decumbent herb used traditionally …

Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies

C Pellacani, G Eleftheriou - Advances in Medical Sciences, 2020 - Elsevier
This review summarizes the adverse effects on the central and/or peripheral nervous
systems that may occur in response to antineoplastic drugs. In particular, we describe the …

Protective effect of naringin against oxaliplatin‐induced peripheral neuropathy in rats: A behavioral and molecular study

HS Semis, FM Kandemir, C Caglayan… - … of Biochemical and …, 2022 - Wiley Online Library
Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer,
but it causes peripheral neuropathy as a dose‐limiting side effect. Herein, we used the rat …

Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-κB and Bcl2 signalling

A Khan, B Shal, AU Khan, KU Shah, SS Zahra… - International …, 2023 - Elsevier
Vincristine (VCR) is a well-known chemotherapeutic agent that frequently triggers
neuropathic pain. Ajugarin-I (Aju-I) isolated from Ajuga bracteosa exerts antioxidant, anti …