Craniosynostosis is a pathologic craniofacial disorder and is defined as the premature
fusion of one or more cranial (calvarial) sutures. Cranial sutures are fibrous joints consisting …

Cranial sutures are dynamic structures in which stem cell biology, bone formation, and
mechanical forces interface, influencing the shape of the skull throughout development and …

Vascularization is critical for skull development, maintenance, and healing. Yet, there
remains a significant knowledge gap in the relationship of blood vessels to cranial skeletal …

Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial
design has led to the fabrication of a plethora of promising devices. Pre‐clinical testing of …

During embryonic development, organs undergo distinct and programmed morphological
changes as they develop into their functional forms. While genetics and biochemical signals …

Craniosynostosis (CS) is the second most prevalent inborn craniofacial malformation; it
results from the premature fusion of cranial sutures and leads to dimorphisms of variable …

All skeletal bones house osteogenic stem cell niches, in which mesenchymal stromal cells
(MSC) provide progenitors for tissue growth and regeneration. They have been widely …

The regeneration of the mammalian skeleton's craniofacial bones necessitates the action of
intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically …

Craniosynostosis, is the premature fusion of one or more cranial sutures which is the second
most common cranial facial anomalies. The premature cranial sutures leads to deformity of …

We have recently demonstrated that c-Jun N-terminal kinase 3 (JNK3) is a key modulator of
the enhanced osteogenic potential of stem cells derived from children when compared to …