The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: clinical implications

P Dumnicka, D Maduzia, P Ceranowicz… - International journal of …, 2017 - mdpi.com
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild
local inflammation to severe systemic involvement resulting in substantial mortality. Early …

Consequences of COVID-19 for the Pancreas

U Abramczyk, M Nowaczyński, A Słomczyński… - International journal of …, 2022 - mdpi.com
Although coronavirus disease 2019 (COVID-19)-related major health consequences involve
the lungs, a growing body of evidence indicates that COVID-19 is not inert to the pancreas …

Noggin inhibits IL-1β and BMP-2 expression, and attenuates cartilage degeneration and subchondral bone destruction in experimental osteoarthritis

SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin… - Cells, 2020 - mdpi.com
Osteoarthritis (OA) is a chronic inflammatory and progressive joint disease that results in
cartilage degradation and subchondral bone remodeling. The proinflammatory cytokine …

Acenocoumarol exerts anti-inflammatory activity via the suppression of NF-κB and MAPK pathways in RAW 264.7 cells

HJ Han, CG Hyun - Molecules, 2023 - mdpi.com
The repurposing of already-approved drugs has emerged as an alternative strategy to
rapidly identify effective, safe, and conveniently available new therapeutic indications …

Protective effect of bergapten in acetic acid-induced colitis in rats

EA Adakudugu, EO Ameyaw, E Obese, RP Biney… - Heliyon, 2020 - cell.com
Abstract Bergapten (5-methoxysporalen) is a furanocoumarin extracted from several species
of citrus and bergamot oil. Bergamot essential oil is used traditionally in the management of …

Identification of AP-1 as a critical regulator of glutathione peroxidase 4 (GPX4) transcriptional suppression and acinar cell ferroptosis in acute pancreatitis

X Ma, X Dong, Y Xu, N Ma, M Wei, X Xie, Y Lu, W Cao… - Antioxidants, 2022 - mdpi.com
Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a
critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are …

Serum concentrations of angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) are associated with coagulopathy among patients with acute pancreatitis

P Dumnicka, B Kuśnierz-Cabala, M Sporek… - International journal of …, 2017 - mdpi.com
In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction
and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include …

Drug D, a diosgenin derive, inhibits L-arginine-induced acute pancreatitis through meditating GSDMD in the endoplasmic reticulum via the TXNIP/HIF-1α pathway

C Zhang, H Niu, C Wan, X Yu, G Xin, Y Zhu, Z Wei, F Li… - Nutrients, 2022 - mdpi.com
Acute pancreatitis (AP) is one of the most common causes of hospitalization for
gastrointestinal diseases, with high morbidity and mortality. Endoplasmic reticulum stress …

[PDF][PDF] Administration of warfarin accelerates the recovery in ischemia/reperfusion-induced acute pancreatitis

D Maduzia, P Ceranowicz, J Cieszkowski… - J. Physiol …, 2020 - jpp.krakow.pl
Acute pancreatitis is associated with activation of coagulation and there is a close
relationship between coagulation and the severity of this disease. Administration of …

Administration of warfarin inhibits the development of cerulein-induced edematous acute pancreatitis in rats

K Konarska-Bajda, P Ceranowicz, J Cieszkowski… - Biomolecules, 2023 - mdpi.com
Acute pancreatitis (AP) is a severe disease with high morbidity and mortality in which
inflammation and coagulation play crucial roles. The development of inflammation leads to …