Alpha1-Antitrypsin Deficiency AAT is a protease inhibitor targeting neutrophil elastase. It
prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our
knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is …

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

Human breath contains many volatile metabolites. However, few breath tests are currently
used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we …

Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) tropism and pathogenesis. Here, we show that …

α1-antitrypsin deficiency (AATD) is a hereditary disorder associated with a risk of developing
liver disease and pulmonary emphysema, and other chronic respiratory disorders (mainly …

Rationale: Intravenous plasma-purified alpha-1 antitrypsin (IV-AAT) has been used as
therapy for alpha-1 antitrypsin deficiency (AATD) since 1987. Previous trials (RAPID and …

Summary Background Alpha-1 Antitrypsin (AAT) deficiency (AATD), the most common
genetic cause of emphysema presents with unexplained phenotypic heterogeneity in …