Prostate cancer is the commonest, non-cutaneous cancer in men. At present, there is no
cure for the advanced, castration-resistant form of the disease. Estrogen has been shown to …

Therapies targeting estrogen receptor α (ERα) including selective estrogen receptor
modulators (SERMs), eg., tamoxifen; selective estrogen receptor downregulators (SERDs) …

Exosomes (EVs) have relevance in cell-to-cell communication carrying pro-tumorigenic
factors that participate in oncogenesis and drug resistance and are proposed to have …

The growth of advanced prostate cancer depends on androgen receptor signalling, however
treatment options are limited. Here we report the disruption of specific protein–protein …

Tumor metastasis is the leading cause of death among breast cancer patients. PELP1
(proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is …

Purpose: We conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer
tissue from patients of lung adenocarcinoma to identify markers for the presence of lymph …

MicroRNAs are small noncoding RNAs that inhibit protein expression. We have previously
shown that the inhibition of the microRNA let-7d in epithelial cells caused changes …

Epithelial–mesenchymal transition (EMT) is implicated in bronchial remodeling and loss of
lung function in chronic inflammatory airway diseases. Previous studies showed the …

ABSTRACT N-myc down-regulated gene 1 (NDRG1) has been shown to regulate tumor
growth and metastasis in various malignant tumors and also to be dysregulated in …

Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein
that has been shown to modulate an increasing number of pathways and biological …