FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer

Z Wang, SL Townley, S Zhang, M Liu, M Li… - Nature …, 2024 - nature.com
FOXA family proteins act as pioneer factors by remodeling compact chromatin structures.
FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal …

FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer

N Liu, A Wang, M Xue, X Zhu, Y Liu, M Chen - Cell Death Discovery, 2024 - nature.com
Abstract FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering
transcription factors that build gene expression capacity and play a central role in biological …

Polymer Physics behind the Gel‐Spinning of UHMWPE Fibers

Z Wang, L Sangroniz, J Xu, C Zhu… - Macromolecular Rapid …, 2024 - Wiley Online Library
Gel‐spinning of ultra‐high molecular weight polyethylene (UHMWPE) fibers has attracted
great interest in academia and industry since its birth and commercialization in the 1980s …

Origin of Melt Memory Effects in Poly (ethylene oxide): The Crucial Role of Entanglements

L Sangroniz, AJ Müller… - Macromolecular Rapid …, 2024 - Wiley Online Library
The melt memory effect on crystallization is an intriguing phenomenon displayed by
semicrystalline polymers, as opposed to low molar mass molecules. It concerns the effect of …

The Isothermal Melting Kinetics of Ultra‐High Molecular Weight Polyethylene Crystals

J Xue, Y Lu, B Wang, J Chen, C Shen… - Macromolecular Rapid …, 2024 - Wiley Online Library
The isothermal melting behaviors of ultra‐high molecular weight polyethylene (UHMWPE)
with different entangled states (ie, nascent and melt‐crystallized samples) are studied. For …

KDM5D histone demethylase mediates p38α inactivation via its enzymatic activity to inhibit cancer progression

J Chen, T Wang, D Zhang, H Wang, Z Huang… - Proceedings of the …, 2024 - pnas.org
The p38 MAP kinase (MAPK) signaling pathway plays pivotal roles in various cellular
processes. Phosphorylation serves as a canonical way to regulate p38α activation through a …

[HTML][HTML] SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma

J Zhang, B Duan, F Li, X Jing, R Li, S Cai… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Abstract SET domain containing 7 (SETD7), a member of histone methyltransferases, is
abnormally expressed in multiple tumor types. However, the biological function and …

Dynamics of polylactic acid under ultrafine nanoconfinement: The collective interface effect and the spatial gradient

S Cheng, D Kogut, J Zheng, S Patil, F Yang… - The Journal of Chemical …, 2024 - pubs.aip.org
Polymers under nanoconfinement can exhibit large alterations in dynamics from their bulk
values due to an interface effect. However, understanding the interface effect remains a …

In silico screening of phytochemicals against chromatin modifier, SETD7 for remodeling of the immunosuppressive tumor microenvironment in renal cancer

N Gadewal, D Patidar, A Natu, S Gupta, V Bastikar - Molecular Diversity, 2024 - Springer
The tumor microenvironment and immune evasion function in a complex cellular network
profoundly challenge the clinical outcome of promising therapies. Our recently published …

Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis …

L Li, J Zhu, Y Chen, H Li, Y Han… - The Journal of Gene …, 2025 - Wiley Online Library
ABSTRACT Background and Objective Osteoarthritis (OA) is characterized by progressive
cartilage degeneration mediated by various molecular pathways, including inflammatory …