Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Lung cancer is one of the most common cancer in the world. In 2018, there were over 2
million new cases of lung cancer and over 1.7 million deaths were attributed to lung cancer …

In recent years, a large number of circRNAs have been identified in mammalian cells with
high-throughput sequencing technologies and bioinformatics. The aberrant expression of …

Abstract Background Cancer‐associated fibroblasts (CAFs) contributes to overall tumor
progression. In the current survey, we explored the ability of microRNA‐20a (miR‐20a) …

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) greatly improve the
survival and quality of life of non-small cell lung cancer (NSCLC) patients with EGFR …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

Cancer resistance to therapy is a big issue in cancer therapy. Tumours may develop some
mechanisms to reduce the induction of cell death, thus stimulating tumour growth. Cancer …

Lung cancer is the most common malignancy and cause of cancer deaths worldwide, owing
to the dismal prognosis for most affected patients. Phosphatase and tensin homolog deleted …