Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Cancer treatment has improved over the past decades, but a major challenge lies in drug
formulation, specifically for oral administration. Most anticancer drugs have poor water …

Zinc (II) complexes of curcumin display moderate cytotoxicity towards cancer cells at low
micromolar concentrations. However, the clinical use of zinc (II) complexes is hampered by …

The solubility behavior of drugs remains one of the most challenging aspects in formulation
development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most …

Fixed-dose combination of atorvastatin calcium (ATV) and ezetimibe (EZT) provides a
considerable advantage in the management of hyperlipidemia. However, both ATV and EZT …

The objective of this study was to develop a thermosensitive in situ gel based on solid
dispersions (SDs) for rectal delivery of ibuprofen (IBU). Thermosensitive (poloxamer 407) …

Valsartan (VAL) is a BCS class II drug with low solubility and high permeability and, thus, its
formulations often encounter low bioavailability problems. Its low bioavailability can be …

Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the
treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and …

In the present study, electrospraying was applied as a novel method for the fabrication of
amorphous nano-solid dispersions (N-SDs) of atorvastatin calcium (ATV), ezetimibe (EZT) …

Background: Ternary solid dispersions have been demonstrated to be an effective strategy
in the improvement of drug absorption and bioavailability. Method: The applications of the …