Roles of human trophoblasts' pattern recognition receptors in host defense and pregnancy complications
K Motomura, M Hara, I Ito, H Morita… - Journal of Reproductive …, 2023 - Elsevier
The immune system in pregnancy is able to protect pregnant mothers and fetuses from
pathogenic microorganisms even while permitting the mother to tolerate the semi-allogenic …
pathogenic microorganisms even while permitting the mother to tolerate the semi-allogenic …
Potential pharmacologic interventions targeting TLR signaling in placental malaria
Complications from placental malaria cause poor pregnancy outcomes, including low
birthweight, preterm delivery, and stillbirths. Many of these complications are driven by …
birthweight, preterm delivery, and stillbirths. Many of these complications are driven by …
Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children
Background Malaria is a deadly disease caused by Plasmodium spp. Several blood
phenotypes have been associated with malarial resistance, which suggests a genetic …
phenotypes have been associated with malarial resistance, which suggests a genetic …
Homeostasis Maintenance in Plasmodium-Infected Placentas: Is There a Role for Placental Autophagy During Malaria in Pregnancy?
A Barateiro, ARC Junior, S Epiphanio… - Frontiers in …, 2022 - frontiersin.org
Malaria represents a significant public health burden to populations living in developing
countries. The disease takes a relevant toll on pregnant women, who are more prone to …
countries. The disease takes a relevant toll on pregnant women, who are more prone to …
Placental malaria is associated with a TLR–Endothelin-3–oxidative damage response in human placenta tissues
S Chenge, M Mbalitsi, H Ngure, M Obimbo, M Singoei… - bioRxiv, 2024 - biorxiv.org
Placental malaria, which is mainly caused by the sequestration of Plasmodium falciparum-
infected erythrocytes in the placenta, is an important driver of poor pregnancy outcomes …
infected erythrocytes in the placenta, is an important driver of poor pregnancy outcomes …