Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

Chronic liver disease (CLD) is a growing health concern which accounts for two million
deaths per year. Obesity, alcohol overconsumption, and progressive cholestasis are …

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive
immune responses. Within tissues, DCs constitute a complex cell population composed of …

Background Monocytes and macrophages play an indispensable role in maintaining
intestinal homeostasis and modulating mucosal immune responses in inflammatory bowel …

The gut epithelium not only provides a physical barrier to separate a noxious outside from a
sterile inside but also allows for highly regulated interactions between bacteria and their …

Crohn's disease (CD) is a chronic inflammatory bowel disease with a high prevalence
throughout the world. The development of Crohn's-related fibrosis, which leads to strictures …

ADAM-like decysin 1 (ADAMDEC1) is a highly conserved metalloprotease which is
exclusively expressed in the gastrointestinal (GI) tract, under healthy state, in various …

Chronic liver disease (CLD) is a growing health concern which accounts for two million
deaths per year. Obesity, alcohol overconsumption, and progressive cholestasis are …