Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Radiation‐induced tissue damage and response

WH McBride, D Schaue - The Journal of pathology, 2020 - Wiley Online Library
Normal tissue responses to ionizing radiation have been a major subject for study since the
discovery of X‐rays at the end of the 19th century. Shortly thereafter, time–dose relationships …

[HTML][HTML] Adult neural stem cells are alerted by systemic inflammation through TNF-α receptor signaling

G Belenguer, P Duart-Abadia, A Jordán-Pla… - Cell stem cell, 2021 - cell.com
Adult stem cells (SCs) transit between the cell cycle and a poorly defined quiescent state.
Single neural SCs (NSCs) with quiescent, primed-for-activation, and activated cell …

Regulating endogenous neural stem cell activation to promote spinal cord injury repair

EAB Gilbert, N Lakshman, KSK Lau, CM Morshead - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

[HTML][HTML] Cognitive effects of low dose of ionizing radiation–Lessons learned and research gaps from epidemiological and biological studies

E Pasqual, F Boussin, D Bazyka, A Nordenskjold… - Environment …, 2021 - Elsevier
The last decades have seen increased concern about the possible effects of low to
moderate doses of ionizing radiation (IR) exposure on cognitive function. An interdisciplinary …

Post-stroke neurogenesis: friend or foe?

MI Cuartero, A García-Culebras… - Frontiers in Cell and …, 2021 - frontiersin.org
The substantial clinical burden and disability after stroke injury urges the need to explore
therapeutic solutions. Recent compelling evidence supports that neurogenesis persists in …

The subventricular zone, a hideout for adult and pediatric high-grade glioma stem cells

A Lombard, M Digregorio, C Delcamp… - Frontiers in …, 2021 - frontiersin.org
Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high
proportion of death due to cancer. This poor prognosis is a direct consequence of tumor …

Quiescent neural stem cells for brain repair and regeneration: lessons from model systems

L Otsuki, AH Brand - Trends in Neurosciences, 2020 - cell.com
Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …

Assessing the role of ependymal and vascular cells as sources of extracellular cues regulating the mouse ventricular-subventricular zone neurogenic niche

S Quaresima, A Istiaq, H Jono, E Cacci… - Frontiers in Cell and …, 2022 - frontiersin.org
Neurogenesis persists in selected regions of the adult mouse brain; among them, the
ventricular-subventricular zone (V-SVZ) of the lateral ventricles represents a major …

Single-cell RNA sequencing of hESC-derived 3D retinal organoids reveals novel genes regulating RPC commitment in early human retinogenesis

X Mao, Q An, H Xi, XJ Yang, X Zhang, S Yuan, J Wang… - Stem cell reports, 2019 - cell.com
The development of the mammalian retina is a complicated process involving the generation
of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific …