Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
Prefrontal cortex and depression
DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
Adolescence as a neurobiological critical period for the development of higher-order cognition
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …
order cognitive abilities and corresponding refinements of the structure and function of the …
High-frequency neuromodulation improves obsessive–compulsive behavior
Nearly one billion people worldwide suffer from obsessive–compulsive behaviors,, yet our
mechanistic understanding of these behaviors is incomplete, and effective therapeutics are …
mechanistic understanding of these behaviors is incomplete, and effective therapeutics are …
Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
In this review, we provide a brief overview over the current knowledge about the role of
dopamine transmission in the prefrontal cortex during learning and memory. We discuss …
dopamine transmission in the prefrontal cortex during learning and memory. We discuss …
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …
Dopamine's actions in primate prefrontal cortex: challenges for treating cognitive disorders
AFT Arnsten, M Wang, CD Paspalas - Pharmacological reviews, 2015 - ASPET
The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and …
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and …
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder …
JW Kanen, KD Ersche, NA Fineberg, TW Robbins… - …, 2019 - Springer
Rationale Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-
compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of …
compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of …
Reversal learning and dopamine: a bayesian perspective
VD Costa, VL Tran, J Turchi… - Journal of …, 2015 - Soc Neuroscience
Reversal learning has been studied as the process of learning to inhibit previously rewarded
actions. Deficits in reversal learning have been seen after manipulations of dopamine and …
actions. Deficits in reversal learning have been seen after manipulations of dopamine and …
A framework for the investigation of rare genetic disorders in neuropsychiatry
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity,
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …