SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19
Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to
severe acute respiratory distress. The severity of the illness can also extend from mild …
severe acute respiratory distress. The severity of the illness can also extend from mild …
[HTML][HTML] Bile reflux and hypopharyngeal cancer
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
[HTML][HTML] Weakly acidic bile is a risk factor for hypopharyngeal carcinogenesis evidenced by DNA damage, antiapoptotic function, and premalignant dysplastic lesions …
Simple Summary The etiologic role of biliary reflux in hypopharyngeal cancer is supported
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
Biliary reflux as a causal factor in hypopharyngeal carcinoma: new clinical evidence and implications
Background Recent preclinical explorations strongly support the tumorigenic potential of bile
on laryngopharyngeal mucosa. Herein, the authors describe, in bile‐related human …
on laryngopharyngeal mucosa. Herein, the authors describe, in bile‐related human …
[HTML][HTML] Pepsin promotes activation of epidermal growth factor receptor and downstream oncogenic pathways, at slightly acidic and neutral pH, in exposed …
Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
MiR‐802 causes nephropathy by suppressing NF‐κB‐repressing factor in obese mice and human
D Sun, J Chen, W Wu, J Tang, L Luo… - Journal of cellular …, 2019 - Wiley Online Library
Obesity is associated with significant microvascular complications including renal injuries
and may induce end‐stage renal disease. Emerging studies have demonstrated microRNAs …
and may induce end‐stage renal disease. Emerging studies have demonstrated microRNAs …
[HTML][HTML] Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
Background The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US
and Western countries. The development of Barrett's esophagus (BE) and its progression to …
and Western countries. The development of Barrett's esophagus (BE) and its progression to …
Curcumin prevents the bile reflux‐induced NF‐κB‐related mRNA oncogenic phenotype, in human hypopharyngeal cells
The presence of bile is not an uncommon finding in acidic oesophageal and extra‐
oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to …
oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to …
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo
Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has
recently been documented as an independent risk factor for NFκB-mediated …
recently been documented as an independent risk factor for NFκB-mediated …
[HTML][HTML] The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal …
Highlights Deregulation in MMR mechanism and miR-21, miR-155 and miR-451a are
caused by chronic exposure to N-Nitrosamines, NNK and NDEA, and nicotine. Reduced …
caused by chronic exposure to N-Nitrosamines, NNK and NDEA, and nicotine. Reduced …