Ever since its discovery by Windhaus, the importance of the active metabolite of vitamin D (1,
25-dihydroxyvitamin D 3; 1, 25-(OH) 2D 3) has been ever expanding. In this review, the …

Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary
hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of …

Vitamin D plays a classical hormonal role in skeletal health by regulating calcium and
phosphorus metabolism. Vitamin D metabolites also have physiological functions in …

Abstract Motivation: Transcription factor (TF) ChIP-seq datasets have particular
characteristics that provide unique challenges and opportunities for motif discovery. Most …

The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

1, 25-Dihydroxyvitamin D3 (1, 25 (OH) 2D3), the biologically active metabolite of Vitamin D3,
not only regulates bone and calcium metabolism but also exerts other biological activities …

The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in
complex with hormonally active vitamin D, 1, 25 (OH) 2D3, regulates the expression of more …

Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors for
its activated form—1α, 25-dihydroxyvitamin D 3—have been identified in both beta cells and …

The vitamin D receptor (VDR) is found in nearly all, if not all, cells in the body. The enzyme
that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1 …

The functions of dendritic cells (DCs) are tightly regulated such that protective immune
responses are elicited and unwanted immune responses are prevented. 1α25 …