Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …

Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …

Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

Mechanisms underlying anti-diabetic effects of GLP1 analogs remain incompletely
understood. We observed that in prediabetic humans exenatide treatment acutely induces …

Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …

Obesity is associated with increased prostate cancer (PCa) progression and higher
mortality, however, the mechanism (s) remain still unclear. Here, we investigated signaling …

Adipose tissue is part of the prostate cancer (PCa) microenvironment not only in the
periprostatic area, but also in the most frequent metastatic sites, such as bone marrow and …

Simple Summary As overweight and obesity increase among the population worldwide, a
parallel increase in the number of individuals diagnosed with prostate cancer was observed …