Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases

TB Ayeleso, MG Matumba, E Mukwevho - Molecules, 2017 - mdpi.com
The increasing demand for natural products as an alternative therapy for chronic diseases
has encouraged research into the pharmacological importance of bioactive compounds from …

Ursolic acid-based derivatives as potential anti-cancer agents: An update

V Khwaza, OO Oyedeji, BA Aderibigbe - International journal of molecular …, 2020 - mdpi.com
Ursolic acid is a pharmacologically active pentacyclic triterpenoid derived from medicinal
plants, fruit, and vegetables. The pharmacological activities of ursolic acid have been …

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

J Wei, J Mu, Y Tang, D Qin, J Duan, A Wu - Journal of nanobiotechnology, 2023 - Springer
Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and
related conditions, pose considerable challenges to effective management and treatment …

Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy

MN Laszczyk - Planta medica, 2009 - thieme-connect.com
Today cancer treatment is not only a question of eliminating cancer cells by induction of cell
death. New therapeutic strategies also include targeting the tumour microenvironment …

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

VP Ribeiro, C Arruda, M Abd El-Salam… - Pharmaceutical …, 2018 - Taylor & Francis
Context: Inflammatory disorders are common in modern life, and medicinal plants provide an
interesting source for new compounds bearing anti-inflammatory properties. In this regard …

[HTML][HTML] Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage

GA Gutiérrez-Rebolledo, AG Siordia-Reyes… - Asian Pacific journal of …, 2016 - Elsevier
Objective To estimate to what extent the mixture of ursolic acid and oleanolic acid, in
addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods …

Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of …

SH Kim, JH Hong, YC Lee - European journal of pharmacology, 2013 - Elsevier
Allergic asthma is a chronic airway disorder characterized by airway hyperresponsiveness
to allergens, chronic airway inflammation, airway edema, increased mucus secretion …

Immunomodulation of Parkinson's disease using Mucuna pruriens (Mp)

SN Rai, H Birla, W Zahra, SS Singh… - Journal of Chemical …, 2017 - Elsevier
Immune control is associated with nigrostriatal neuroprotection for Parkinson's disease (PD);
though its direct cause and effect relationships have not yet been realized and modulating …

Recent advances in the chemistry and biology of oleanolic acid and its derivatives

N Verma, DS Raghuvanshi, RV Singh - European Journal of Medicinal …, 2024 - Elsevier
The pentacyclic triterpenes represent a significant class of plant bioactives with a variety of
structures and a wide array of biological activities. These are biosynthetically produced via …