Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-
associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy …

Background The leading cause of cancer-related mortality worldwide is lung cancer, and its
clinical outcome and prognosis are still unsatisfactory. The understanding of potential …

Evidence for research over the past decade shows that epigenetic regulation mechanisms
run through the development and prognosis of tumors. Therefore, small molecular …

Epigenetic modulation, including acetylation, methylation, phosphorylation, and
ubiquitination, plays a pivotal role in regulation of gene expression. Histone acetylation—a …

Background Histone deacetylase (HDAC) overexpression has been documented in various
cancers and may be associated with worse outcomes. Data from early-phase studies of …

The deacetylation process regulated by histone deacetylases (HDACs) plays an important
role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which …

A fragment recruitment process was conducted to pinpoint a suitable fragment for installation
in the HDAC inhibitory template to furnish agents endowed with the potential to treat lung …

The significance of epigenetic modulation, involving acetylation, methylation, as well as
ubiquitination has been indicated in the regulation of gene expression and tumor …