Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …

Integral membrane proteins of the cell surface and most intracellular compartments of
eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and …

Hundreds of proteins are inserted post-translationally into the endoplasmic reticulum (ER)
membrane by a single carboxy-terminal transmembrane domain (TMD). During targeting …

A large group of diverse, functionally important, and differently localized transmembrane
proteins, share a particular membrane topology, consisting of a cytosolic N-terminal region …

Proper localization of membrane proteins is essential for the function of biological
membranes and for the establishment of organelle identity within a cell. Molecular …

BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in
a variety of seemingly unrelated physiological and pathological processes, such as …

Biosynthesis of membrane proteins requires that hydrophobic transmembrane (TM) regions
be shielded from the cytoplasm while being directed to the correct membrane. Tail-anchored …

Hundreds of eukaryotic membrane proteins are anchored to membranes by a single
transmembrane domain at their carboxyl terminus. Many of these tail-anchored (TA) proteins …

Many tail-anchored (TA) membrane proteins are targeted to and inserted into the
endoplasmic reticulum (ER) by theguided entry of tail-anchored proteins'(GET) pathway …

The recently elucidated Get proteins are responsible for the targeted delivery of the majority
of tail-anchored (TA) proteins to the endoplasmic reticulum. Get4 and Get5 have been …