Medicinal plants: An invaluable, dwindling resource in sub-Saharan Africa

M Moyo, AO Aremu, J Van Staden - Journal of Ethnopharmacology, 2015 - Elsevier
Ethnopharmacological relevance The use of plant species for different therapeutic/medicinal
purposes is well-entrenched in sub-Saharan Africa. Aim of the review To provide a critical …

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Z Liang, A Currais, D Soriano-Castell… - Pharmacology & …, 2021 - Elsevier
Mitochondria are the primary source of energy production in the brain thereby supporting
most of its activity. However, mitochondria become inefficient and dysfunctional with age and …

Back to the future with phenotypic screening

M Prior, C Chiruta, A Currais, J Goldberg… - ACS Chemical …, 2014 - ACS Publications
There are no disease-modifying drugs for any old age associated neurodegenerative
disease or stroke. This is at least in part due to the failure of drug developers to recognize …

The neuroprotective flavonoids sterubin and fisetin maintain mitochondrial health under oxytotic/ferroptotic stress and improve bioenergetic efficiency in HT22 …

M Goujon, Z Liang, D Soriano-Castell, A Currais… - Antioxidants, 2024 - mdpi.com
The global increase in the aging population has led to a rise in many age-related diseases
with continuing unmet therapeutic needs. Research into the molecular mechanisms …

[HTML][HTML] 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory …

S Gunesch, M Hoffmann, C Kiermeier, W Fischer… - Redox Biology, 2020 - Elsevier
Alzheimer's disease (AD) is a multifactorial disease and the most common form of dementia.
There are no treatments to cure, prevent or slow down the progression of the disease …

Pharmacology of herbal sexual enhancers: a review of psychiatric and neurological adverse effects

P Brunetti, AF Lo Faro, A Tini, FP Busardò, J Carlier - Pharmaceuticals, 2020 - mdpi.com
Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances
increasing libido alter the concentrations of specific neurotransmitters or sex hormones in …

Ethnobotanical study aimed at investigating the use of medicinal plants to treat nervous system diseases in the Rif of Morocco

N Chaachouay, O Benkhnigue, L Zidane - Journal of chiropractic medicine, 2020 - Elsevier
Objective The aim of this study was to assess the knowledge and use of medicinal plants in
the treatment of neurological diseases in the Rif region of northern Morocco. Methods An …

Optimization of Hyperglycemic Induction in Zebrafish and Evaluation of Its Blood Glucose Level and Metabolite Fingerprint Treated with Psychotria malayana Jack …

K Benchoula, A Khatib, FMC Quzwain… - Molecules, 2019 - mdpi.com
A standard protocol to develop type 1 diabetes in zebrafish is still uncertain due to
unpredictable factors. In this study, an optimized protocol was developed and used to …

[HTML][HTML] The genus Psychotria: phytochemistry, chemotaxonomy, ethnopharmacology and biological properties

NO Calixto, MEF Pinto, SD Ramalho… - Journal of the Brazilian …, 2016 - SciELO Brasil
Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose
genus comprising approximately 1600 species. The available references demonstrate that …

Alkaloids from apocynaceae: origin, pharmacotherapeutic properties, and structure-activity studies

A Dey, A Mukherjee, M Chaudhury - Studies in Natural Products Chemistry, 2017 - Elsevier
Alkaloids are a diverse group of naturally occurring secondary compounds derived from
amino acids or the process of transamination. Some synthetic compounds with similar …