Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood.
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …

Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion in
Cardiology Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into
human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal …