Simple Summary The chorioallantoic membrane of an avian embryo is a simple, low-cost,
low-maintenance, and well-available in vivo animal model with many advantages in the field …

Over the past century, the chick embryo model, historically employed for research in
developmental biology, has become a valuable tool for cancer research. The characteristics …

Background: Challenges in developing drugs for pancreatic ductal adenocarcinoma (PDAC)
include obtaining metastatic cancer tissue for research and validating biomarkers …

P38α/β has been described as a tumor-suppressor controlling cell cycle checkpoints and
senescence in epithelial malignancies. However, p38α/β also regulates other cellular …

Transplantation of human kidney-derived cells is a potential therapeutic modality for
promoting regeneration of diseased renal tissue. However, assays that determine the ability …

Osteosarcoma is amongst the most common primary malignant tumors of bone and occurs
in adolescents and young adults. Current treatment is a combination of both surgery and …

Bisphosphonates (BPs) are nonhydrolysable pyrophosphate analogs with high affinity to
hydroxyapatite (HAP, bone mineral) and are mainly used for treatment of various bone …

Osteosarcoma (OS) is amongst the most commonly diagnosed bone tumors occurring in
adolescence, young adults and adults over the age of 65. Current treatment is based on a …

Background: The best current xenograft model of multiple myeloma (MM) in immune-
deficient non-obese diabetic/severe-combined immunodeficient mice is costly, animal …

Glioblastoma multiforme (GBM) is an incurable brain cancer. Despite tmultimodal therapies,
most patients experience recurrence within a year and the median survival is only 15 …