Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

Stem cells are self-renewing cells that can differentiate into specialized cell type (s).
Pluripotent stem cells, ie embryonic stem cells (ESC) or induced pluripotent stem cells …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Abstract Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative
degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in …

The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of
cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal …

Blood vessel stability is essential for embryonic development; in the adult, many diseases
are associated with loss of vascular integrity. The ETS transcription factor ERG drives …

Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …

Shigella invades the human intestinal mucosa, thus causing bacillary dysentery, an acute
recto-colitis responsible for lethal complications, mostly in infants and toddlers. Conversely …

Angiogenesis involves the formation of new blood vessels and is critical for fundamental
events such as development and repair after injury. Perturbances in angiogenesis contribute …

Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful …