Targeting natural killer cells in cancer immunotherapy
Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …
Allogeneic natural killer cell therapy
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia
Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-
specific targets has significantly hampered the development of effective immune-based …
specific targets has significantly hampered the development of effective immune-based …
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute
myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia …
myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia …
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
R Romee, S Cooley, MM Berrien-Elliott… - Blood, The Journal …, 2018 - ashpublications.org
New therapies for patients with hematologic malignancies who relapse after allogeneic
hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15 (IL-15) is a cytokine …
hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15 (IL-15) is a cytokine …
Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant
JJ Bednarski, C Zimmerman… - Blood, The Journal …, 2022 - ashpublications.org
Pediatric and young adult (YA) patients with acute myeloid leukemia (AML) who relapse
after allogeneic hematopoietic cell transplantation (HCT) have an extremely poor prognosis …
after allogeneic hematopoietic cell transplantation (HCT) have an extremely poor prognosis …
iPSC-derived natural killer cell therapies-expansion and targeting
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …
development, especially use against hematologic malignancies. Clinical trials of NK cell …
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
NK cells, lymphocytes of the innate immune system, are important for defense against
infectious pathogens and cancer. Classically, the CD56dim NK cell subset is thought to …
infectious pathogens and cancer. Classically, the CD56dim NK cell subset is thought to …
The role of cytokines in the regulation of NK cells in the tumor environment
GM Konjević, AM Vuletić, KMM Martinović, AK Larsen… - Cytokine, 2019 - Elsevier
Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
[HTML][HTML] Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect
M Felices, AJ Lenvik, R McElmurry, S Chu, P Hinderlie… - JCI insight, 2018 - ncbi.nlm.nih.gov
NK cell–based immunotherapies have been gaining traction in the clinic for treatment of
cancer. IL-15 is currently being used in number of clinical trials to improve NK cell expansion …
cancer. IL-15 is currently being used in number of clinical trials to improve NK cell expansion …