The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development and have challenged our fundamental understanding of how to …
Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …
Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia; evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …
MA Sikking, SLVM Stroeks, OJ Waring… - Journal of the …, 2023 - Am Heart Assoc
Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow abnormality induced by age‐related DNA mutations, which give rise to proinflammatory …
S Hermouet - Frontiers in Oncology, 2023 - frontiersin.org
Knowledge on the myeloproliferative neoplasms (MPNs)–polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF)–has accumulated since the discovery of …
Somatic TP53 mutations are prevalent in normal tissue but little is known about their association with cancer risk. Cervical liquid-based cytology (LBC), commonly known as Pap …
OBJECTIVE Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion …
D Tran, JS Beeler, J Liu, B Wiley, ICC Chan, Z Xin… - Clinical Cancer …, 2024 - AACR
Purpose: Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN). Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk …
S Hermouet, HC Hasselbalch - Blood Advances, 2024 - ashpublications.org
Long before the discovery of the JAK2, CALR, and MPL mutations, chronic inflammation was an established characteristic of BCR-ABL–negative myeloproliferative neoplasms (MPNs) …