We report efficient syntheses of the clinical agent cladribine (2-chloro-2 '-deoxyadenosine,
CldAdo), which is the drug of choice against hairy-cell leukemia and other neoplasms, from …

Indolocarbazole glycosides are balanced between two conformations: a “closed”
conformation containing a cyclic hydrogen bond between the indolocarbazole NH and the …

In the present work, we suggested anion exchange resins in the phosphate form as a source
of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ …

2-Chloro-2′-deoxyadenosine (Cladribine) chemotherapeutic drug has been studied
experimentally in solid state by 35Cl NQR and NMR–NQR double resonance and …

The title compound, C9H12N6O3, shows a syn-glycosylic bond orientation [χ= 64.17 (16)°].
The 2′-deoxyfuranosyl moiety exhibits an unusual C1′-exo–O4′-endo (1T0; S-type) …

A concise synthesis of 2'-deoxyisoguanosine is achieved whereby 2, 6-dichloropurine is
glycosylated using the Hoffer sugar to give a pair of beta-configured nucleoside N9/N7 …

We have synthesized two types of [6-15N]-deoxyadenosine analogs:[6-15N]-2′-
deoxyadenosine (1) and [6-15N]-2-chloro-2′-deoxyadenosine ([6-15N]-cladribine, 2) …

The title compound (C 8 H 10 N 4 O 2) is monoclinic, with a= 7.740 (2), b= 17.044 (7), c=
6.992 (3) Å, β= 100.60 (1)°, and space group P 2 1/c. Two O-methyl groups are coplanar …

We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which
is one of the candidate substances for treating Alzheimer's disease, and subsequently …

The present invention is a method for preparing 2-halo-6-aminopurines, and more
specifically for preparing the clinical agent cladribine (2-chloro-2′-deoxyadenosine …