Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

Memory T cells that are specific for one virus can become activated during infection with an
unrelated heterologous virus, and might have roles in protective immunity and …

Antigen discovery technologies have largely focused on major histocompatibility complex
(MHC) class I-restricted human T cell receptors (TCRs), leaving methods for MHC class II …

The multiple sclerosis (MS)-associated HLA major histocompatibility complex (MHC) class II
alleles DRB1* 1501, DRB5* 0101 and DQB1* 0602 are in strong linkage disequilibrium …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Immune memory responses to previously encountered pathogens can sometimes alter the
immune response to and the course of infection of an unrelated pathogen by a process …

The relative roles of CD8, TCR: pepMHC affinity, and TCR: pepMHC dissociation rate in T
cell activation have remained controversial. To determine the relationships among these …

▪ Abstract T cells constantly sample their environment using receptors (TCR) that possess
both a germline-encoded low affinity for major histocompatibility complex (MHC) molecules …

T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they
have binding affinities that are several orders of magnitude lower. It has been suggested that …

T cell responsiveness to an epitope is affected both by its affinity for the presenting MHC
molecule and the affinity of the MHC-peptide complex for TCR. One limitation of cancer …