Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Degradation of basement membranes and stromal extracellular matrix (ECM) is crucial for
invasion and metastasis of malignant cells. Degradation of ECM is initiated by proteinases …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

This review focuses on the process of enamel maturation, a series of events associated with
slow, progressive growth in the width and thickness of apatitic crystals. This developmental …

The biomineralization of the dental enamel matrix with a carbonated hydroxyapatite mineral
generates one of the most remarkable examples of a vertebrate mineralized tissue. Recent …