Aging is a natural consequence of a society developing process. Although many adults
retain good hearing as they aging, hearing loss related with age–presbycusis which can …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Hearing loss due to damage to auditory hair cells is normally irreversible because
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …

For mammalian cochlear hair cells, fate determination is normally completed by birth. We
report here that overexpression of Math1, a mouse homolog of the Drosophila gene atonal …

In mammals, the permanence of acquired hearing loss is mostly due to the incapacity of the
cochlea to replace lost mechanoreceptor cells, or hair cells. In contrast, damaged vestibular …

AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-
kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

In the cellular program leading to DNA synthesis, signals that drive cells into S-phase
converge at the level of CDK activity. The products of at least three different gene families …

The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory
supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both …

Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and
supporting cells. Notch signalling is thought to govern this pattern of differentiation through …