Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

There are still gaps in our understanding of the complex processes by which p53
suppresses tumorigenesis. Here we describe a novel role for p53 in suppressing the …

The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

All living organisms depend on primary and secondary membrane transport for the supply of
external nutrients and removal or sequestration of unwanted (toxic) compounds. Due to the …

The ATP‐binding cassette (ABC) transporters belong to a large protein family predominantly
present in diverse species. ABC transporters are driven by ATP hydrolysis and can act as …