Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022 - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

[HTML][HTML] The gut microbiota derived metabolite trimethylamine N-oxide: its important role in cancer and other diseases

Y Zhou, Y Zhang, S Jin, J Lv, M Li, N Feng - Biomedicine & …, 2024 - Elsevier
An expanding body of research indicates a correlation between the gut microbiota and
various diseases. Metabolites produced by the gut microbiota act as mediators between the …

Contribution of trimethylamine N-oxide (TMAO) to chronic inflammatory and degenerative diseases

LA Constantino-Jonapa, Y Espinoza-Palacios… - Biomedicines, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has
been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in …

Gut microbiota modulation as a novel therapeutic strategy in cardiometabolic diseases

YB Mutalub, M Abdulwahab, A Mohammed… - Foods, 2022 - mdpi.com
The human gut harbors microbial ecology that is in a symbiotic relationship with its host and
has a vital function in keeping host homeostasis. Inimical alterations in the composition of …

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

M Gawałko, TA Agbaedeng, A Saljic… - Cardiovascular …, 2022 - academic.oup.com
Recent preclinical and observational cohort studies have implicated imbalances in gut
microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a …

Gut microbiota dependant trimethylamine N-oxide and hypertension

KH Mutengo, SK Masenga, A Mweemba… - Frontiers in …, 2023 - frontiersin.org
The human gut microbiota environment is constantly changing and some specific changes
influence the host's metabolic, immune, and neuroendocrine functions. Emerging evidence …

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products

M Aschner, AV Skalny… - International …, 2023 - spandidos-publications.com
The aim of the present review was to summarize the potential interactive effects between the
gut microbiota and advanced glycation end‑product (AGE) accumulation and toxicity in the …

Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway

ZS Luo, XC Yu, C Wang, HY Zhao, X Wang… - Journal of physiology …, 2024 - Springer
Recently, trimethylamine N-oxide (TMAO) has been considered a risk factor for
cardiovascular disease and has a proatherogenic effect. Many studies have found that …

Cellular senescence in brain aging and cognitive decline

A Shafqat, S Khan, MH Omer, M Niaz… - Frontiers in aging …, 2023 - frontiersin.org
Cellular senescence is a biological aging hallmark that plays a key role in the development
of neurodegenerative diseases. Clinical trials are currently underway to evaluate the …