Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
CC Robertson, RM Elgamal, BA Henry-Kanarek… - Molecular …, 2024 - Elsevier
Abstract Type 1 diabetes (T1D) is a complex multi-system disease which arises from both
environmental and genetic factors, resulting in the destruction of insulin-producing …
environmental and genetic factors, resulting in the destruction of insulin-producing …
An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells
CL Bayly, XQ Dai, C Nian, PC Orban, CB Verchere… - Molecular …, 2024 - Elsevier
Objective Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to
study diabetes pathologies and develop cell replacement therapies. Although current …
study diabetes pathologies and develop cell replacement therapies. Although current …
Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human islets
TJJ de Winter, M Sovrovic, E Dekker, N de Graaf… - bioRxiv, 2025 - biorxiv.org
Gene regulatory networks (GRN) must be robust to maintain cellular identity across
individuals yet flexible to accommodate population genetic variants. Therefore, comparing …
individuals yet flexible to accommodate population genetic variants. Therefore, comparing …
Crosstalk between the aryl hydrocarbon receptor and hypoxia inducible factor 1α pathways impairs downstream dioxin response in human islet models
The incidence of type 2 diabetes (T2D) is increasing globally at a rate that cannot be
explained solely by genetic predisposition, diet, or lifestyle. Epidemiology studies report …
explained solely by genetic predisposition, diet, or lifestyle. Epidemiology studies report …
Exploring the link between dioxin exposure and diabetes risk: contributions of the islet aryl hydrocarbon receptor
N Gang - 2024 - repository.library.carleton.ca
Abstract Type 2 diabetes (T2D) is a chronic condition where insulin-secreting pancreatic β-
cell mass and function is compromised. Etiology is traditionally linked to genetic …
cell mass and function is compromised. Etiology is traditionally linked to genetic …