1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Reactive oxygen species (ROS) are byproducts of aerobic metabolism and potent agents
that cause oxidative damage. In oxygenic photosynthetic organisms such as cyanobacteria …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …

The observation that purified yeast glutamine synthetase is rapidly inactivated in a thiol-
containing buffer yet retains activity in crude extracts containing the same thiol led to our …

The phospholipase A2 (PLA2) superfamily consists of a broad range of enzymes defined by
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …

The reactivities of glutathione, cysteine, cysteamine, penicillamine, N-acetylcysteine,
dithiothreitol and captopril with superoxide generated from xanthine oxidase and …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …