Fungal pathogens threaten human health both directly as infectious agents and indirectly by
limiting crop production, and new approaches are desperately needed to combat fungal …

Fungal pathogens cause life-threatening diseases in humans, and the increasing
prevalence of these diseases emphasizes the need for new targets for therapeutic …

The pathogenic fungus Cryptococcus neoformans must overcome iron limitation to cause
disease in mammalian hosts. Previously, we reported a screen for insertion mutants with …

Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Heme trafficking is a fundamental biological process, yet its direct study has been hampered
due to heme's tight intracellular regulation, heme cytotoxicity, and the transient nature of …

Small GTPases of the Rab family coordinate multiple membrane fusion and trafficking
events in eukaryotes. In fungi, the Rab GTPase, Ypt7, plays a critical role in late endosomal …

Heme is produced in plants via a plastid-localized metabolic pathway and is subsequently
distributed to all cellular compartments. In addition to covalently and noncovalently bound …

Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate
species; a reaction catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme …

Vacuoles are dynamic cellular organelles, and their morphology is altered by various stimuli
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal …

Although largely overlooked compared to bacterial infections, fungal infections pose a
significant threat to the health of humans and other organisms. Many pathogenic fungi …