Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Wallerian axon degeneration is a form of programmed subcellular death that promotes axon
breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases …

Axon degeneration is a hallmark of many neurodegenerative disorders. The current
assumption is that the decision of injured axons to degenerate is cell-autonomously …

In this review, we first provide a brief historical perspective, discussing how peripheral nerve
injury (PNI) may have caused World War I. We then consider the initiation, progression, and …

In spite of tremendous research efforts we have not yet achieved two of our principal
therapeutic goals in the treatment of Parkinson's disease (PD), to prevent its onward …

Axon degeneration is a characteristic event in many neurodegenerative conditions including
stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate …